Search results for "Cognitive aging"
showing 10 items of 14 documents
Multitasking in aging: ERP correlates of dual-task costs in young versus low, intermediate, and high performing older adults
2018
Abstract With large inter-individual variability, older adults show a decline in cognitive performance in dual-task situations. Differences in attentional processes, working memory, response selection, and general speed of information processing have been discussed as potential sources of this decline and its between-subject variability. In comparison to young subjects (n = 36, mean age: 25 years), we analyzed the performance of a large group of healthy elderly subjects (n = 138, mean age: 70 years) in a conflicting dual-task situation (PRP paradigm). Based on their dual-task costs (DTCs), the older participants were clustered in three groups of high, medium, and low performing elderly. DTC…
Reward motivation and neurostimulation interact to improve working memory performance in healthy older adults: A simultaneous tDCS-fNIRS study.
2019
Abstract Several studies have evaluated the effect of anodal transcranial direct current stimulation (tDCS) over the prefrontal cortex (PFC) for the enhancement of working memory (WM) performance in healthy older adults. However, the mixed results obtained so far suggest the need for concurrent brain imaging, in order to more directly examine tDCS effects. The present study adopted a continuous multimodal approach utilizing functional near-infrared spectroscopy (fNIRS) to examine the interactive effects of tDCS combined with manipulations of reward motivation. Twenty-one older adults (mean age = 69.7 years; SD = 5.05) performed an experimental visuo-spatial WM task before, during and after …
Age and Semantic Inhibition Measured by the Hayling Task: A Meta-Analysis.
2016
Objective Cognitive aging is commonly associated with a decrease in executive functioning (EF). A specific component of EF, semantic inhibition, is addressed in the present study, which presents a meta-analytic review of the literature that has evaluated the performance on the Hayling Sentence Completion test in young and older groups of individuals in order to assess the magnitude of the age effect. Method A systematic search involving Web of Science, PsyINFO, PsychARTICLE, and MedLine databases and Google Scholar was performed. A total of 11 studies were included in this meta-analysis, encompassing a total of 887 participants; 440 young and 447 older adults. The effect sizes for group dif…
Association of interleukin-6 rs1800796 polymorphism with reduced cognitive performance in healthy older adults
2019
© 2018 Elsevier B.V. With increasing life expectancy, age-associated cognitive impairment is an escalating problem worldwide. Inflammation is one of the features that characterises cognitive decline and can stimulate neurodegeneration. Interleukin 6 (IL-6) is a cytokine frequently associated with a pro-inflammatory phenotype and increased levels have been associated with the pathogenesis of dementia. The rs1800796 polymorphism in the promoter region of IL-6 gene was previously shown to influence IL-6 expression and therefore we hypothesised this gene polymorphism would be associated with IL-6 plasma levels and cognitive performance of older adults. The present study investigated the associa…
Age and sex related changes in episodic memory function in middle aged and older adults
2014
Age-related change in episodic memory function is commonly reported in older adults. When detected on neuropsychological tests, it may still be difficult to distinguish normal from pathological changes. The present study investigates age-and sex-related changes in a group of healthy middle-aged and older adults, participating in a three-wave study on cognitive aging. The California Verbal Learning test (CVLT-II) was used to assess their episodic memory function. A cross-sectional analysis of results from the first wave showed higher performance in females than males, with a steeper age-related decline in males. This was confirmed in a longitudinal analysis using a mixed effects regression m…
Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance
2017
International audience; Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand 10 (CXCL10) was found to be higher in older adults, compared with young, and negatively associated with working memory performance. This coincided with an age-related reduction in blood DNA methylation at specific CpGs within the CXCL10 gene promoter. In vitro analysis supported the role of DNA methylation in regulating CXCL10 transcription. A polymorph…
The relevance of nutrition for the concept of cognitive frailty
2016
Purpose of review Physical and cognitive frailty are interrelated and synergistic syndromes more frequently seen in old age, which represent intermediate stages between aging successfully and disability. Poor nutrition is a fundamental determinant for both conditions, while various dietary components are proposed to prevent and/or improve them. This updated review discusses the possible influence of nutritional factors on cognitive frailty and its potential mediators. Recent findings Oxidative stress, low-grade systemic inflammation, neuroinflammation, and altered autophagy, all associated with obesity, metabolic syndrome and insulin resistance, are proposed mechanisms to explain the influe…
Association between osteocalcin and cognitive performance in healthy older adults.
2016
INTRODUCTION: cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults.METHODS: this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor …
Vascular ageing and the related complications in the brain: New insights on related mechanisms and their translational applications
2021
s consequence of “populations aging phenomenon”, the burden of incessant increase of incidence and prevalence of neurodegenerative diseases (NeuroDegD) is becoming very alarming, as well as it is gaining an important attention the developing of intervention measures, essen-tially preventive. Of consequence, the knowledge of primordial Neuro-DegD causes, and the related mechanisms, appears to be fundamental. Consistent with this, growing evidence reports a close link of the vascular aging, dysfunction and diseases with the onset and progression of NeuroDegD.
Information retrieval in digital documents : towards a variation of procedure patterns
2013
The research activity of information on the internet has become common in our daily life. Despite this fact, it still raises many problems for the user who does not find the information they want or is lost to the amount of information available. This study aims at testing a new patented preview device, enabling users to browse and view pages in depth. The task is to find a target apartment with one or more specific criteria in a real estate agency designed website. Several conditions were tested. The “usual” condition with the classic search features, page by page, the other "transparent" condition which enables you to preview selected pages and select only relevant pages. We are intereste…